The clash comes just three days after South Africa rounds off their 2017 Gabon African Cup of Nations qualifiers against Mauritania.
This will be the third time Egypt and South Africa meet in the annual Nelson Mandela Challenge.
The two nations locked horns for the first time in the 5th Edition played at FNB Stadium on 16 December, 1998.
The hosts won 2-1.
The two African giants met again on 15 November 2006, this time on neutral ground in Brentfort, London in England.
The North Africans emerged 1-0 winners in the 12th Edition.